Protein Details: Aquaporin-9

Protein ID

ICDB_Pro_0633

Protein Name

Aquaporin-9

Gene Name

Aqp9

Organism

Rattus norvegicus (Rat)

Length

295 amino acids

AlphaFoldDB

AF-P56627-F1-model_v4.pdb

Function

Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small; non-charged solutes including carbamides; polyols; purines; and pyrimidines.

Sequence

MPSEKDGAKKSLMQRLALKSRIAKETLSEFLGTFIMIVLGCSSIAQAVLSRERFGGIITINIGFASAVVMALYVTFGISGGHINPAVSFAMCAFGRMEWFKFPFYVGAQFLGAFVGAATVFGIYYDGLMAFAGGKLLVVGENATAFIFATYPAPFISTPGAFVDQVVSTMFLLLIVFAMFDSRNLGVPRGLEPVVIGLLIIVLSCSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFTVGNNFWWIPVVGPMIGAFLGGLIYILFIQMHHSKLDPDMKAEPSENNLEKHELSVIM

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in testis and liver. Detected in immature spermatocytes and in interstitial Leydig cells.

DOI ID

10.1074/jbc.273.38.24737; 10.1080/15216549900201333; 10.1101/gr.2596504

RefSeq

NP_075249.1; XP_006243424.1; XP_008764558.1